Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its Prevention by T-817 MA
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چکیده
منابع مشابه
Blocking Effects of Human Tau on Squid Giant Synapse Transmission and Its Prevention by T-817 MA
Filamentous tau inclusions are hallmarks of Alzheimer's disease and related neurodegenerative tauopathies, but the molecular mechanisms involved in tau-mediated changes in neuronal function and their possible effects on synaptic transmission are unknown. We have evaluated the effects of human tau protein injected directly into the presynaptic terminal axon of the squid giant synapse, which affo...
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The release of transmitter substance from the presynaptic terminal of the squid giant synapse, in the absence of action potentials, has been among the most useful experimental paradigms in the study of chemical synaptic transmission (Bloedel et al., 1966; Katz and Miledi, 1967; Kusano et al., 1967). Early experiments using this technique demonstrated that neither sodium nor potassium currents w...
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ژورنال
عنوان ژورنال: Frontiers in Synaptic Neuroscience
سال: 2011
ISSN: 1663-3563
DOI: 10.3389/fnsyn.2011.00003